New research reveals that as abdominal fat increases, the brain’s memory center, the hippocampus, shrinks, and markers of Alzheimer’s disease, such as beta amyloid plaques and tau tangles, begin to appear. These changes can occur as early as a person’s 40s and 50s, decades before cognitive decline becomes apparent.
Beta amyloid plaques and tau tangles are key biomarkers of Alzheimer’s progression, with amyloid often appearing first. The study highlights the role of visceral fat—a deeper, more harmful fat encasing internal organs—in triggering inflammation and disrupting insulin processing, which can accelerate brain atrophy and increase amyloid and tau deposits.
Key Findings from the Study
A pilot study of 80 participants, averaging 49 years old and with a BMI of 32 (obese), utilized abdominal MRIs and PET scans to measure visceral fat and Alzheimer’s biomarkers. Researchers observed:
- Increased visceral fat correlates with higher amyloid and tau levels.
- Visceral fat contributes to brain atrophy in the hippocampus, a hallmark of Alzheimer’s disease.
- Individuals with more visceral fat exhibited greater insulin resistance, which can exacerbate metabolic and cognitive issues.
According to data from the World Health Organization, obesity is a global epidemic.
“This work is impactful for the millions of people showing early signs of Alzheimer’s,” said Dr. Richard Isaacson, a preventive neurologist, who emphasized the importance of focusing on visceral fat reduction.
Combatting Visceral Fat to Protect Brain Health
Experts suggest targeted approaches to reduce visceral fat, which include:
- Tracking Body Composition: Use biometric scales or annual DEXA scans to monitor body fat.
- Exercise Smarter: Engage in “Zone 2 training,” like brisk walking at a steady pace for 45–60 minutes, two to three times a week, ensuring you can talk but just barely.
- Build Muscle Mass: Strength training twice a week and maintaining adequate protein intake boost metabolism and fat-burning efficiency.
Reducing belly fat through these methods not only improves physical health but also reduces the risk of Alzheimer’s-related brain changes, offering a proactive way to combat this devastating disease.
